DASH trial
Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage


ISRCTN 67038373
Room S/D2108, Stroke Trials Unit
School of Medicine, University of Nottingham
Queen's Medical Centre, Derby Road
Nottingham NG7 2UH, United Kingdom
Serious Adverse Event categories

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DASH SAE sub-categories
(as of 17 Jun 2020 at 14:39 BST)

* - commonly expected after desmopressin

Cardiovascular
29 Acute coronary syndrome (ACS)
1404 Angina
136 Angina - unstable (UA)
1414 Arterial thrombosis (any site)
41 Atrial fibrillation (AF) or atrial flutter
46 Bradycardia
424 Cardiac (mural) thrombus
10 Cardiac dysrhythmia
9 * Cardiac failure or pulmonary oedema
431 Carotid dissection
48 Chest pain (NOT cardiac)
7 Deep vein thrombosis (DVT)
441 Endocarditis
83 Hypertension
1447 * Hypervolemia (fluid overload)
14 Hypotension
171 Left atrial myxoma
304 Myocardial infarction (NSTEMI)
305 Myocardial infarction (STEMI)
421 Patent foramen ovale (PFO)
168 Peripheral arterial disease
1416 Peripheral artery embolism
1441 Presyncope
8 Pulmonary embolism (PE)
170 Sudden cardiac death (SCD)
303 Supraventricular tachycardia (SVT)
1442 Syncope
165 Systemic embolism
130 Tachycardia
1417 Venous thrombosis (any site)
 
Nervous system
30 * Agitation / aggression
1403 Alzheimer's disease
36 Anxiety - apprehension
184 Brain tumour - primary
185 Brain tumour - secondary
24 Cerebral oedema
1 Complication of initial stroke
1427 Cortical vein thrombosis
53 Dementia
54 Depression
1419 Disturbance in colour vision
1405 Dizziness
1433 Expansion of haemorrhagic stroke - with hydrocephalus
1434 Expansion of haemorrhagic stroke - without hydrocephalus
1425 Extension of ischaemic stroke
180 Extra dural bleed
27 Haemorrhagic transformation (of infarct, HTI)
1406 Hallucinations
25 * Headache
1423 Hydrocephalus
6 Intracerebral bleed (recurrent haemorrhagic stroke)
419 Intracranial aneurysm
1415 Ischaemic stroke
1396 Loss of consciousness
38 Nerve entrapment
1424 Neurological deterioration
120 Sedation
17 * Seizure / convulsions
121 Sensory loss
1430 Stroke - undetermined / no imaging
183 Sub-arachnoid haemorrhage
182 Subdural haematoma
134 Transient ischaemic attack (TIA)
140 Vertigo
141 Visual loss
143 Weakness
 
Respiratory
1435 Acute type 1 respiratory failure
40 Asthma
152 Bronchitis
47 Bronchospasm
26 Chest infection
153 Chronic obstructive pulmonary disease (COPD)
1449 COVID-19 / SARS-CoV-2 infection
162 Emphysema
164 Exacerbation of COPD
86 Hypoxia
1402 Interstitial pneumonitis
161 Pleural effusions
2 Pneumonia
435 Pneumothorax
200 Primary lung cancer
202 Pulmonary fibrosis
1431 Respiratory tract infection, lower (LRI/LRTI)
1426 Respiratory tract infection, upper (URI/URTI)
201 Secondary lung cancer
124 Shortness of breath
 
Gastro-intestinal
28 * Abdominal pain
167 Bowel ischaemia
194 Carcinoma bowel
156 Cholecystitis
1401 Colitis
52 Constipation
56 Diarrhoea
193 Diverticulitis
60 Dysphagia
160 Gall stones
1394 Gastroenteritis
23 Gastrointestinal bleed
71 Gastrointestinal disturbance
1393 Gastrointestinal infarction
1422 Haematemesis
77 Heartburn
78 Hepatitis
1421 Hernia
87 Incontinence, faecal
1397 Liver/hepatic impairment/dysfunction
163 Melaena
101 * Nausea
191 Oesophagitis
104 Oral ulceration
105 Pancreatitis
192 Peptic ulcer
1395 PR bleed
195 Primary liver carcinoma
196 Secondary liver metastasis
64 Stomatitis
142 * Vomiting
1448 * Weight gain
145 Weight loss
 
Genito-urinary
197 Carcinoma bladder
1410 Glomerulonephritis
1428 Haematuria
88 Incontinence, urinary
198 Primary renal tumour
1420 Prostate cancer
428 Renal cyst
118 Renal impairment/failure
123 Sexual dysfunction
138 Urinary retention
15 Urinary tract infection (UTI)
 
Haematological/immunological
1411 Agranulocytosis/granulocytopenia
437 * Allergic reaction
81 Anaemia
33 * Anaphylactic reaction
1443 * Angioedema
82 Aplastic anaemia
85 Eosinophilia
150 Leukopenia
157 Lymphadenopathy
92 Methaemoglobinaemia
1412 Neutropaenia
1413 Pancytopenia
427 Polycythaemia
132 Thrombocytopenia
90 Thrombotic thrombocytopenic purpura (TTP)
1444 Urticaria
91 Vasculitis
 
Metabolic/endocrine
151 Acid base disturbance
1399 Dehydration
430 Diabetes
55 Diaphoresis
61 Electrolyte disturbance
79 Hyperglycaemia
84 Hyperuricaemia
158 Hypoglycaemia
1446 * Hyponatremia (low sodium)
 
Musculoskeletal/cutaneous
220 Arthralgia
221 Arthritis (not specified)
1407 Bullous dermatitis
155 Cellulitis
1429 Cramps
1408 Eczema
67 Fall
70 Flushing
1391 Fracture / fractured bone
222 Gout
95 Muscle twitching
223 Myalgia
224 Myositis
159 Osteoarthritis
1390 Pressure ulcer
1409 * Pruritus
116 * Rash
225 Rheumatoid arthritis
 
Miscellaneous
42 Bacteraemia - septicaemia
16 Death unattended
12 Extracranial bleeding (not GI haemorrhage)
68 Fatigue - malaise
128 Fever
4 Infection (not otherwise specified)
13 Malignancy/cancer
1445 MRSA infection
146 Other (please state medical condition)
1398 Septicaemia
1432 Suicide
144 Tumour - benign
133 Tumour - malignant