TICH-3 trial
Tranexamic acid for IntraCerebral Haemorrhage 3


ISRCTN 97695350
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Room S/D2108, Stroke Trials Unit
School of Medicine, University of Nottingham
Queen's Medical Centre, Derby Road
Nottingham NG7 2UH, United Kingdom
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  • Serious Adverse Events (SAEs) — we have a legal responsibility to collect all safety events occurring within the first 7 days after randomisation (including SARs/SUSARs/fatal SAEs).
  • Safety events include: venous thromboembolism; ischaemic events (arterial thrombosis at any site, ischaemic stroke, transient ischaemic attack, peripheral artery embolism, myocardial infarction, acute coronary syndrome) and seizures.
  • Please remember that fatal SAEs need to be reported, even if after 7 days - unless death occurred after discharge from hospital.
  • Please assess if expected according to RSI.  Expectedness should only be assessed in events that are thought to be possibly/probably/definitely related to the IMP.
  • Investigators have a legal responsibility to report applicable SAEs to the chief investigator without delay, within 24 hours.

Latest recruiting hospitals
The National Hospital for Neurology & Neurosurgery (UCLH), London, UK
Hospital Universitario de A Coruña, A Coruña, Spain
Hospital Sultanah Bahiyah, Kedah, Malaysia
UKM Medical Centre, Federal Territory Kuala Lumpur, Malaysia
Hospital Queen Elizabeth, Sabah, Malaysia
Hospital Sultanah Aminah, Johor, Malaysia
Helsinki University Hospital, Helsinki, Finland
ASST Ovest Milanese, Legnano, Italy
Eastbourne General District Hospital, Eastbourne, UK
Leicester Royal Infirmary, Leicester, UK
Victoria Hospital, Kirkcaldy, UK
Lincoln County Hospital, Lincoln, UK
Azienda Ospedalieria di Rilievo Nazionale Antonio Cardarelli, Napoli, Italy
Cheltenham General Hospital, Cheltenham, UK
Addenbrooke's Hospital, Cambridge, UK
  
Average time to randomisation (last 6 months)
# Hours Hospital
1 0.8 Uppsala University Hospital, Uppsala, Sweden
3 1.9 Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
5 2.1 Aarhus University Hospital, Aarhus, Denmark
3 2.1 LTD Pineo Medical Ecosystem, Tbilisi, Georgia
1 2.3 Royal United Hospital Bath, Bath, UK
1 2.3 University Hospitals Monkland, Airdrie, UK
1 2.3 Hospital Sultanah Bahiyah, Kedah, Malaysia
4 2.3 Royal Victoria Hospital, Belfast, UK
26 2.3 Bispebjerg Hospital, Copenhagen, Denmark
21 2.3 Helsinki University Hospital, Helsinki, Finland
6 2.3 Azienda Ospedalieria di Rilievo Nazionale Antonio Cardarelli, Napoli, Italy
1 2.3 Arrowe Park Hospital, Wirral, UK
9 2.5 St. George's Hospital, London, UK
6 2.5 Odense University Hospital, Odense, Denmark
1 2.5 Mater Misericordiae University Hospital, Dublin, Republic of Ireland
13 2.6 ASST Ovest Milanese, Legnano, Italy
3 2.6 Lincoln County Hospital, Lincoln, UK
15 2.6 The Royal Victoria Infirmary, Newcastle Upon Tyne, UK
5 2.6 Derriford Hospital, Plymouth, UK
12 2.7 Hospital Universitari Vall d'Hebron, Barcelona, Spain
5 2.7 Royal London Hospital, London, UK
6 2.7 Aberdeen Royal Infirmary, Aberdeen, UK
1 2.7 Hospital UiTM, Selangor, Malaysia
3 2.7 New Cross Hospital, Wolverhampton, UK
6 2.7 Eastbourne General District Hospital, Eastbourne, UK
2 2.8 Hôpital André Mignot, Le Chesnay, France
4 2.8 Aalborg University Hospital, Aalborg, Denmark
1 2.8 Sunderland Royal Hospital, Tyne and Wear, UK
8 2.9 Hôpital Universitaire de la Pitié-Salpêtrière, Paris, France
16 2.9 Hospital Universitario de A Coruña, A Coruña, Spain
14 2.9 Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain
5 2.9 Norfolk and Norwich University Hospital, Norwich, UK
1 2.9 Southampton General Hospital, Southampton, UK
1 2.9 Kent & Canterbury Hospital, Canterbury, Kent, UK
12 3.0 CHU Lyon, Lyon, France
1 3.0 Yeovil District Hospital, Somerset, UK
4 3.0 Hospital Queen Elizabeth II, Sabah, Malaysia
6 3.0 Royal Preston Hospital, Preston, UK
1 3.0 Musgrove Park Hospital, Taunton, UK
1 3.1 Milton Keynes University Hospital, Milton Keynes, UK
5 3.1 Hôpital Foch, Suresnes, France
2 3.1 Whiston Hospital, Merseyside, UK
6 3.1 Royal Stoke University Hospital, Stoke-on-Trent, UK
9 3.1 Leicester Royal Infirmary, Leicester, UK
6 3.1 University Hospital of North Durham, Durham, UK
2 3.2 Hospital Seberang Jaya, Pulau Pinang, Malaysia
6 3.2 Cheltenham General Hospital, Cheltenham, UK
6 3.2 James Cook University Hospital, Middlesbrough, UK
8 3.2 LEPL The First University Clinic of Tbilisi State, Tbilisi, Georgia
9 3.2 Presidio Ospedale San Carlo, Milano, Italy
12 3.2 Hospital Queen Elizabeth, Sabah, Malaysia
2 3.3 Watford General Hospital, Watford, UK
2 3.3 Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
1 3.3 Hospital Tuanku Jaafar, Seremban, Negeri Sembilan, Malaysia
21 3.3 The National Hospital for Neurology & Neurosurgery (UCLH), London, UK
16 3.3 UKM Medical Centre, Federal Territory Kuala Lumpur, Malaysia
4 3.3 Tallaght University Hospital, Dublin, Republic of Ireland
7 3.4 Hôpital Pierre Paul Riquet, Toulouse, France
3 3.4 Southmead Hospital, Bristol, UK
3 3.4 Hôpital Pellegrin Bordeaux, Bordeaux, France
4 3.4 Ninewells Hospital, Dundee, UK
2 3.4 Azienda USL Toscana Nord Ovest, Massa, Italy
1 3.4 CHU Rouen, Rouen, France
8 3.4 Charing Cross Hospital, London, UK
4 3.4 Centre Hospitalier Sainte‐Anne, Paris, France
1 3.4 Aintree University Hospital, Liverpool, UK
5 3.5 Craigavon Area Hospital, Portadown, UK
6 3.5 Hôpital Nord Laennec, Nantes, France
2 3.5 Salford Royal Hospital, Salford, UK
4 3.5 Hospital Sultanah Aminah, Johor, Malaysia
2 3.6 Hull Royal Infirmary, Hull, UK
3 3.6 York Hospital, York, UK
1 3.6 Luton and Dunstable University Hospital, Luton, UK
6 3.6 King's College Hospital, London, UK
6 3.6 Addenbrooke's Hospital, Cambridge, UK
2 3.6 Hôpital Lariboisière, Paris, France
7 3.6 Kantonsspital St.Gallen, St. Gallen, Switzerland
9 3.6 Centre Hospitalier Sud Francilien, Paris, France
3 3.7 West Suffolk Hospital, Bury St Edmunds, UK
3 3.7 Victoria Hospital, Kirkcaldy, UK
7 3.7 Ipswich Hospital, Ipswich, UK
3 3.7 Hôpital Jean Minjoz, Besançon, France
4 3.7 University Hospital of North Tees, Stockton on Tees, UK
4 3.8 Morriston Hospital, Swansea, UK
2 3.8 Royal Bournemouth Hospital, Bournemouth, UK
5 3.8 Queen's Medical Centre, Nottingham, UK
2 3.8 Royal Infirmary of Edinburgh, Edinburgh, UK
1 3.8 Countess of Chester Hospital, Chester, UK
1 3.9 Rigshospitalet, Copenhagen, Denmark
1 4.0 University Hospital Coventry, Coventry, UK
3 4.0 Royal Derby Hospital, Derby, UK
4 4.1 Hospital Tengku Ampuan Rahimah, Selangor, Malaysia
2 4.1 University Hospital, Cardiff, UK
2 4.2 Queen Elizabeth Hospital Birmingham, Birmingham, UK
1 4.3 University Hospital Hairmyres, East Kilbride, UK
1 4.3 ASST di Mantova, Mantova, Italy
2 4.3 Hôpital Roger Salengro, Lille, France
1 4.4 CHU Poitiers, Poitiers, France
1 4.5 Glan Clwyd Hospital, Denbighshire, UK
1 4.5 Antrim Area Hospital, Antrim, UK
1 4.6 Peterborough City Hospital, Peterborough, UK
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