TICH-3 trial
Tranexamic acid for IntraCerebral Haemorrhage 3


ISRCTN 97695350
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Room S/D2108, Stroke Trials Unit
School of Medicine, University of Nottingham
Queen's Medical Centre, Derby Road
Nottingham NG7 2UH, United Kingdom
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  • Serious Adverse Events (SAEs) — we have a legal responsibility to collect all safety events occurring within the first 7 days after randomisation (including SARs/SUSARs/fatal SAEs).
  • Safety events include: venous thromboembolism; ischaemic events (arterial thrombosis at any site, ischaemic stroke, transient ischaemic attack, peripheral artery embolism, myocardial infarction, acute coronary syndrome) and seizures.
  • Please remember that fatal SAEs need to be reported, even if after 7 days - unless death occurred after discharge from hospital.
  • Please assess if expected according to RSI.  Expectedness should only be assessed in events that are thought to be possibly/probably/definitely related to the IMP.
  • Investigators have a legal responsibility to report applicable SAEs to the chief investigator without delay, within 24 hours.

Latest recruiting hospitals
Centre Hospitalier Sud Francilien, Paris, France
Queen's Medical Centre, Nottingham, UK
Helsinki University Hospital, Helsinki, Finland
Northumbria Specialist Emergency Care Hospital, Northumberland, UK
Whiston Hospital, Merseyside, UK
Aarhus University Hospital, Aarhus, Denmark
Milton Keynes University Hospital, Milton Keynes, UK
Hospital Universitario de A Coruña, A Coruña, Spain
University Hospital, Cardiff, UK
Odense University Hospital, Odense, Denmark
UKM Medical Centre, Federal Territory Kuala Lumpur, Malaysia
Hull Royal Infirmary, Hull, UK
Hospital Seberang Jaya, Pulau Pinang, Malaysia
Hospital Queen Elizabeth, Sabah, Malaysia
CHU Lyon, Lyon, France
  
Average time to randomisation (last 6 months)
# Hours Hospital
1 0.8 Uppsala University Hospital, Uppsala, Sweden
2 1.7 LTD Pineo Medical Ecosystem, Tbilisi, Georgia
1 1.8 Southend University Hospital, Essex, UK
3 1.9 Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
4 2.2 Azienda Ospedalieria di Rilievo Nazionale Antonio Cardarelli, Napoli, Italy
1 2.3 Royal United Hospital Bath, Bath, UK
6 2.3 Royal Victoria Hospital, Belfast, UK
7 2.4 Aarhus University Hospital, Aarhus, Denmark
1 2.4 Milton Keynes University Hospital, Milton Keynes, UK
3 2.5 Norfolk and Norwich University Hospital, Norwich, UK
8 2.5 St. George's Hospital, London, UK
9 2.6 Aalborg University Hospital, Aalborg, Denmark
1 2.6 Leeds General Infirmary, Leeds, UK
5 2.6 Royal London Hospital, London, UK
6 2.6 Eastbourne General District Hospital, Eastbourne, UK
2 2.6 New Cross Hospital, Wolverhampton, UK
19 2.6 Helsinki University Hospital, Helsinki, Finland
12 2.6 The Royal Victoria Infirmary, Newcastle Upon Tyne, UK
3 2.6 Lincoln County Hospital, Lincoln, UK
13 2.6 Hospital Universitario de A Coruña, A Coruña, Spain
13 2.6 ASST Ovest Milanese, Legnano, Italy
24 2.6 Bispebjerg Hospital, Copenhagen, Denmark
2 2.7 Azienda USL Toscana Nord Ovest, Massa, Italy
2 2.8 Hôpital André Mignot, Le Chesnay, France
2 2.8 Kent & Canterbury Hospital, Canterbury, Kent, UK
14 2.8 CHU Lyon, Lyon, France
15 2.8 Hospital Universitari Vall d'Hebron, Barcelona, Spain
2 2.8 University Hospitals Monkland, Airdrie, UK
1 2.8 Sunderland Royal Hospital, Tyne and Wear, UK
8 2.8 Hôpital Universitaire de la Pitié-Salpêtrière, Paris, France
3 2.9 Hospital Sultanah Bahiyah, Kedah, Malaysia
15 2.9 Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain
4 3.0 Hospital Queen Elizabeth II, Sabah, Malaysia
8 3.0 Odense University Hospital, Odense, Denmark
6 3.0 Royal Preston Hospital, Preston, UK
1 3.0 Musgrove Park Hospital, Taunton, UK
5 3.1 Leicester Royal Infirmary, Leicester, UK
2 3.1 Ninewells Hospital, Dundee, UK
7 3.1 Aberdeen Royal Infirmary, Aberdeen, UK
9 3.1 Hôpital Nord Laennec, Nantes, France
5 3.1 Southmead Hospital, Bristol, UK
6 3.1 Royal Stoke University Hospital, Stoke-on-Trent, UK
9 3.2 Presidio Ospedale San Carlo, Milano, Italy
7 3.2 James Cook University Hospital, Middlesbrough, UK
8 3.2 LEPL The First University Clinic of Tbilisi State, Tbilisi, Georgia
3 3.2 Whiston Hospital, Merseyside, UK
2 3.3 Watford General Hospital, Watford, UK
1 3.3 Hospital Tuanku Jaafar, Seremban, Negeri Sembilan, Malaysia
3 3.3 University Hospital of North Durham, Durham, UK
5 3.3 Hospital Sultanah Aminah, Johor, Malaysia
2 3.3 Royal Infirmary of Edinburgh, Edinburgh, UK
4 3.3 Northumbria Specialist Emergency Care Hospital, Northumberland, UK
18 3.3 Hospital Queen Elizabeth, Sabah, Malaysia
1 3.3 Mater Misericordiae University Hospital, Dublin, Republic of Ireland
3 3.3 Rigshospitalet, Copenhagen, Denmark
6 3.3 Cheltenham General Hospital, Cheltenham, UK
17 3.3 UKM Medical Centre, Federal Territory Kuala Lumpur, Malaysia
5 3.3 Hôpital Foch, Suresnes, France
3 3.3 Hull Royal Infirmary, Hull, UK
4 3.3 Tallaght University Hospital, Dublin, Republic of Ireland
2 3.4 Centre Hospitalier Sainte‐Anne, Paris, France
8 3.4 Hôpital Pierre Paul Riquet, Toulouse, France
3 3.4 Hôpital Jean Minjoz, Besançon, France
17 3.4 The National Hospital for Neurology & Neurosurgery (UCLH), London, UK
1 3.4 Aintree University Hospital, Liverpool, UK
7 3.4 King's College Hospital, London, UK
4 3.5 Craigavon Area Hospital, Portadown, UK
7 3.5 Kantonsspital St.Gallen, St. Gallen, Switzerland
3 3.5 Addenbrooke's Hospital, Cambridge, UK
8 3.6 Ipswich Hospital, Ipswich, UK
1 3.6 Southampton General Hospital, Southampton, UK
3 3.6 Derriford Hospital, Plymouth, UK
2 3.6 Hôpital Lariboisière, Paris, France
2 3.7 York Hospital, York, UK
5 3.7 Charing Cross Hospital, London, UK
5 3.7 Victoria Hospital, Kirkcaldy, UK
7 3.7 Queen's Medical Centre, Nottingham, UK
1 3.8 Luton and Dunstable University Hospital, Luton, UK
10 3.8 Centre Hospitalier Sud Francilien, Paris, France
4 3.8 Morriston Hospital, Swansea, UK
3 3.8 Salford Royal Hospital, Salford, UK
4 3.8 University Hospital, Cardiff, UK
2 3.9 Royal Derby Hospital, Derby, UK
1 3.9 Antrim Area Hospital, Antrim, UK
2 3.9 Hôpital Pellegrin Bordeaux, Bordeaux, France
3 4.0 Hôpital Roger Salengro, Lille, France
3 4.0 ASST di Mantova, Mantova, Italy
3 4.0 West Suffolk Hospital, Bury St Edmunds, UK
7 4.0 Hospital Tengku Ampuan Rahimah, Selangor, Malaysia
4 4.1 University Hospital of North Tees, Stockton on Tees, UK
2 4.2 Glan Clwyd Hospital, Denbighshire, UK
3 4.2 Hospital Seberang Jaya, Pulau Pinang, Malaysia
1 4.3 Queen Elizabeth Hospital Birmingham, Birmingham, UK
1 4.3 University Hospital Hairmyres, East Kilbride, UK
2 4.4 CHU Rouen, Rouen, France
1 4.6 Peterborough City Hospital, Peterborough, UK
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